Assessing Disease Severity Based on Laboratory Parameters in Acute Biliary Pancreatitis: A Retrospective Cohort Study

INTRODUCTION: Acute pancreatitis is a progressive disease with inflammation of the pancreas. As the severity of the disease increases, its morbidity and mortality increase, so early diagnosis and treatment are very important. Therefore, many scoring methods are used to predict the prognosis of the disease. In this study, we aimed to show the severity of the disease with some biochemical parameters based on the radiological stage.
METHODS: 104 patients who had acute biliary pancreatitis in EskisehirOsmangaziUniversityFaculty of Medicine Hospital General Surgery Clinic were retrospectively detected. Age, gender, co-morbidity, laboratory parameters, length of stay, and radiological stages of these patients were evaluated. Balthazar scoring system was used to provide disease severity and radiological staging and standardization.
RESULTS: Of 104 patients with acute biliary pancreatitis, 46 were men and 58 were women, and the average age was 60. The length of stay was 9,33 (±9,81). There were 16 patients who underwent cholecystectomy earlier. Of the 26 patients had a history of an additional disease. As the severity of the disease increased, the length of hospital stay also increased. There was a positive correlation between disease severity and amylase, ALT, and glucose levels. There was a negative correlation between calcium level and disease severity and length of stay.
DISCUSSION AND CONCLUSION: As the disease gets more severe, it increases morbidity and mortality, and early evaluation increases the success of the treatment. Simple laboratory examinations can guide the severity of the disease, as in our study. High amylase, ALT values and low calcium levels can determine the prognosis of disease.

Akut Biliyer Pankreatitte Hastalýk Þiddetinin Laboratuvar Parametrelerine Göre Deðerlendirilmesi: Retrospektif Kohort Çalýþmasý

GÝRÝÞ ve AMAÇ: Akut pankreatit, pankreas iltihabý ile seyreden ilerleyici bir hastalýktýr. Hastalýðýn þiddeti arttýkça morbidite ve mortalitesi arttýðý için erken taný ve tedavi çok önemlidir. Bu nedenle hastalýðýn prognozunu tahmin etmek için birçok skorlama yöntemi kullanýlmaktadýr. Bu çalýþmada radyolojik evreye dayalý olarak bazý biyokimyasal parametrelerle hastalýðýn þiddetini göstermeyi amaçladýk.
YÖNTEM ve GEREÇLER: Eskiþehir Osmangazi Üniversitesi Týp Fakültesi Hastanesi Genel Cerrahi Kliniðinde akut biliyer pankreatit tanýsý alan 104 hasta retrospektif olarak tespit edildi. Bu hastalarýn yaþ, cinsiyet, komorbidite, laboratuvar parametreleri, kalýþ süreleri ve radyolojik evreleri deðerlendirildi. Hastalýk þiddeti, radyolojik evreleme ve standardizasyonu saðlamak için Balthazar skorlama sistemi kullanýldý.
BULGULAR: Akut biliyer pankreatitli 104 hastanýn 46'sý erkek, 58'i kadýn olup, bu hastalarýn yaþ ortalamasý 60 olarak bulundu. Bu hastalarýn yatýþ süresi 9,33 (±9,81) idi. Hastalýk öncesi kolesistektomi yapýlan 16 hasta vardý. Ek hastalýk öyküsü olan 26 hasta vardý.
Hastalýðýn þiddeti arttýkça hastanede kalýþ süresi de uzadý. Hastalýk þiddeti ile amilaz, ALT ve glukoz seviyeleri arasýnda pozitif bir iliþki vardý. Kalsiyum düzeyi ile hastalýk þiddeti ve kalýþ süresi arasýnda negatif bir iliþki vardý.

TARTIÞMA ve SONUÇ: Hastalýk aðýrlaþtýkça morbidite ve mortaliteyi artýrmakta, erken deðerlendirme tedavi baþarýsýný artýrmaktadýr. Basit laboratuvar tetkikleri, çalýþmamýzda olduðu gibi hastalýðýn þiddetine rehberlik edebilir. Yüksek amilaz, ALT deðerleri ve düþük kalsiyum seviyeleri akut pankreatitin prognozunu belirleyebilir.