Comparison of Vitamin D Values in Infertile and Fertile Patients

INTRODUCTION: Vitamin D is a steroid hormone and 1,25 dihidroxy vitamin D3 is the active form. Vitamin D acts via it’s spesific reseptor VDR( vitamin D receptor). This receptor has also been identified in reproductive organs such as the ovary, endometrium, testis and pituitary. This has increased the interest in investigating the role of vitamin D in human reproductive health.Vitamin D plays important role in oogenesis, antimullerian hormone(AMH) production and endometrial reseptivity.In this study,it was aimed to determine the role of vitamin D in fertility.
METHODS: Between January 2020- June 2020 months in Kocaeli Provincial Directorate of Health Sciences University Derince Education and Research Hospital,this research was carried out by retrospective screening of the data of 100 primary infertility and 100 fertile patients.Vitamin D levels in both groups were mutually examine.The necessary ethics committee permission has been obtained for the study.
RESULTS: : In the study,the blood vitamin D levels of 20-40 years old patients who applied to the outpatient clinic due to primary infertility were able to conceive 1 or more spontaneously and were compared with the fertile group between the ages 20-40.When vitamin D levels of fertile and infertile women participating in the study were compared,no significiant difference was found between the two groups.
DISCUSSION AND CONCLUSION: Although vitamin D is involved in the physiology of various organ systems,its role in ovarian function and reproductive physiology has not been fully elucidated yet. According to the results of current studies, vitamin D level does not have a direct effect on fertility. More prospective studies are needed to explain the role of vitamin D on ovarian function, especially in the infertil patient group.

Ýnfertil Ve Fertil Hastalarýn Vitamin D Deðerlerinin Karþýlaþtýrýlmasý

GÝRÝÞ ve AMAÇ: D vitamini steroid bir hormondur ve aktif form 1,25-dihidroksi vitamin D3’tür. Biyolojik aktivitesini vitamin D reseptörü(VDR) üzerinden gösterir. Bu reseptör over, endometrium, testis, hipotalamus ve hipofiz gibi üreme organlarýnda da tanýmlanmýþtýr. Bu da D vitamininin insan üreme saðlýðýndaki rolunü araþtýrmaya yönelik ilgiyi arttýrmýþtýr Oosit geliþmesinde, antimüllerian hormon (AMH) üretiminde, endometrium reseptivitesinde rolü vardýr. Bu çalýþmada Vitamin D‘nin fertilitedeki yerini tespit etmek amaçlanmýþtýr.
YÖNTEM ve GEREÇLER: Bu araþtýrma Kocaeli ili Saðlýk Bilimleri Üniversitesi Derince Eðitim Araþtýrma Hastanesine Ocak 2020-Haziran 2020 aylarý arasýnda hastanenin infertilite polikliniðine baþvuran 100 primer infertil hasta ve 100 fertil hastanýn datalarý retrospektif olarak taranmasýyla gerçekleþmiþtir. Her iki grupta vitamin D seviyeleri karþýlýklý olarak incelenmiþtir. Çalýþma için gerekli etik kurul izni alýnmýþtýr.
BULGULAR: Araþtýrmada primer infertilite nedeniyle polikliniðe baþvuran 20-40 yaþ arasý hastalarýn kan vitamin D deðerleri 1 veya daha fazla spontan gebe kalabilmiþ yine 20-40 yaþ arasý fertil grupla kýyaslanmýþtýr. Çalýþmaya katýlan fertil ve infertil kadýnlarýn D vitamini düzeyleri karþýlaþtýrýldýðýnda iki grup arasýnda anlamlý fark bulunmamýþtýr.(p>0.05)
TARTIÞMA ve SONUÇ: D vitamini çeþitli organ sistemlerinin fizyolojisinde yer almasýna raðmen, over fonksiyonu ve üreme fizyolojisindeki rolü henüz tam olarak aydýnlatýlamamýþtýr. Mevcut çalýþmalarýn sonuçlarýna göre D vitamini düzeyinin fertiliteye direkt etkisi yoktur. Özellikle infertil hasta grubunda D vitamininin overin fonksiyonu üzerindeki rolünü açýklamak için daha fazla prospektif çalýþma yapmak gerekmektedir.