Relationship Between uMMP7 and Prognosis, Comorbidity and Mortality in Acute Kidney Injury

INTRODUCTION: uMMP7 is a molecule that has been associated with a wide range of diseases in recent years. Our aim in this study is to examine the relationship of uMMP7 with comorbid conditions, short-term mortality and acute kidney injury (AKI) prognosis in patients hospitalized in our clinic due to AKI.

METHODS: 160 patients who were followed up in our clinic with the diagnosis of AKI were included in the study. The relationship among age, gender, creatinine level at admission, basal creatinine level, post-discharge creatinine level, initial glomerular filtration rate (GFR), basal GFR, control GFR, comorbidities, transition to permanent renal replacement therapy (RRT), mortality and uMMP7 levels of the patients were examined.

RESULTS: Results: Of the comorbid diseases, the uMMP7 level was found to be significantly lower only in hypertension patients(p=.001).This was associated with the use of angiotensin converting enzyme inhibitor (ACEI). A significant and positive relationship was found between the uMMP7 level and the creatinine level at admission, and a statistically significant and negative relationship was found with the GFR level at admission. According to the AKIN criteria, the uMMP7 level of Grade 3 patients was significantly higher than those who are grade 1 or grade 2(p=.004). According to the RIFLE criterion, the uMMP7 level of grade 3 patients was found to be significantly higher compared to the grade 2 patients.

DISCUSSION AND CONCLUSION: As the severity of AKI increases, uMMP7 level increases. uMMP7 level was significantly lower in hypertension patients, and this was associated with the use of ACEI.

Akut Böbrek Hasarýnda uMMP7 ile Prognoz, Komorbidite ve Mortalite Arasýndaki Ýliþki

GÝRÝÞ ve AMAÇ: Amaç: uMMP7 son yýllarda çok çeþitli hastalýklarla iliþkilendirilen bir moleküldür. Bu çalýþmadaki amacýmýz akut böbrek hasarý (ABH) nedeniyle kliniðimizde yatan hastalarda uMMP7'nin komorbid durumlar, mortalite ve kýsa dönem ABH prognozu ile iliþkisini incelemektir.

YÖNTEM ve GEREÇLER: Kliniðimizde ABH tanýsýyla takip edilen 160 hasta çalýþmaya dahil edildi. Yaþ, cinsiyet, baþvuru anýndaki kreatinin düzeyi, bazal kreatinin düzeyi, taburculuk sonrasý kreatinin düzeyi, baþlangýç glomerüler filtrasyon hýzý (GFR), bazal GFR, kontrol GFR, komorbiditeler, kalýcý renal replasman tedavisine (RRT) geçiþ, mortalite ve Hastalarýn uMMP7 düzeylerine bakýldý.

BULGULAR: Komorbid hastalýklardan uMMP7 düzeyi sadece hipertansiyon hastalarýnda anlamlý olarak düþük bulundu (p=0,001). Bu durum anjiyotensin dönüþtürücü enzim inhibitörü (ACEI) kullanýmý ile iliþkiliydi. Baþvuru anýndaki UMMP-7 düzeyi ile kreatinin düzeyi arasýnda anlamlý ve pozitif bir iliþki, baþvuru anýndaki GFR düzeyi ile ise istatistiksel olarak anlamlý ve negatif iliþki bulunmuþtur. AKIN kriterine göre evre 3 hastalarýn idrar MMP7 düzeyi, evre 1 ve evre 2 olanlara göre anlamlý derecede yüksekti(p=0,004). RIFLE kriterine göre 3. derece hastalarýn uMMP7 düzeyi 2. derece hastalara göre anlamlý olarak yüksek bulunmuþtur.


TARTIÞMA ve SONUÇ: ABH'nin þiddeti arttýkça uMMP7 düzeyi de artmaktadýr. Hipertansiyon hastalarýnda uMMP7 düzeyi anlamlý derecede düþüktü ve bu durum ACEI kullanýmýyla iliþkiliydi.