Kocaeli Med J. 2021; 10(3): 331-337 | DOI: 10.5505/ktd.2021.75133

Cholesterol Levels in Subclinical Hypothyroidism and the Effect of Levothyroxine Treatment on Cholesterol Levels

Ýlyas Tenlik¹, Ömer Öztürk², Mustafa Kaplan², Hasan Ali Altunbas^3
1Ankara City Hospital, Department of Gastroenterology, Ankara, Turkey
²Memorial Kayseri Hospital, Department of Gastroenterology, Ankara, Turkey
³Akdeniz University Faculty of Medicine, Department of Endocrinology, Antalya, Turkey

INTRODUCTION: In this study, fasting and postprandial cholesterol levels were investigated in patients diagnosed with subclinical hypothyroidism (SH), and it was investigated whether thyroxine treatment had an effect on these cholesterol levels.
METHODS: Newly diagnosed 50 SH and 25 euthyroid patients were included in the study. The first 25 patients with SH were the treatment group (group I) and the second 25 patients with SH were the control group without treatment (group II).
RESULTS: At the first admission, fasting and postprandial glucose, fasting fT4 and fT3 levels were significantly lower in patients with subclinical hypothyroidism compared to euthyroid patients, while fasting TSH levels were higher. There was no significant difference in other parameters. According to these results, it was observed that whether the patients had SH or not did not affect the fasting or postprandial cholesterol levels of the patients. At the end of the third month, basal and postprandial values were compared between the groups that received treatment with subclinical hypothyroidism (group 1) and those who did not receive treatment (Group 2). While fasting and postprandial total cholesterol and TSH values were statistically significantly higher in the untreated group, fT4 and fT3 values were significantly lower. However, the amount of change in cholesterol levels (delta 0-3 months) was evaluated and no statistical difference was observed.
DISCUSSION AND CONCLUSION: No difference was found in terms of cholesterol profile in both fasting and postprandial periods in patients with SH compared to euthyroid control group. There was no improvement in fasting or postprandial cholesterol levels with thyroxine treatment.

Keywords: subclinical hypothyroidism, serum cholesterol, HDL, LDL, trygliceride

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Subklinik Hipotiroidide Kolesterol Düzeyleri ve Levotiroksin Tedavisinin Kolesterol Düzeyleri Etkisi

Ýlyas Tenlik¹, Ömer Öztürk², Mustafa Kaplan², Hasan Ali Altunbas^3
1Ankara Þehir Hastanesi, Gastroenteroloji Kliniði, Ankara, Türkiye
²Memorial Kayseri Hastanesi, Gastroenteroloji Kliniði, Kayseri, Türkiye
³Akdeniz Üniversitesi Týp Fakültesi Endokrinoloji Bilim Dalý, Antalya, Türkiye

GÝRÝÞ ve AMAÇ: Bu çalýþmada subklinik hipotiroidi (SH) tanýsý alan hastalarda açlýk ve postprandial kolestrol düzeyleri araþtýrýlmýþ ve tiroksin tedavisinin bu kolestrol düzeylerine etkisinin olup olmadýðý incelenmiþtir.
YÖNTEM ve GEREÇLER: Çalýþmaya yeni taný almýþ 50 SH’li ve 25 ötiroid hasta alýndý. Baþvuran ilk 25 SH’li hasta tedavi grubunu (grup I) ve ikinci 25 SH’li hasta tedavi almayan kontrol grubunu (grup II) oluþturdu.
BULGULAR: Ýlk baþvuruda subklinik hipotiroidili hastalarda ötiroid olanlara göre, açlýk ve postprandial glukoz, açlýk sT4 ve sT3 düzeyleri anlamlý olarak daha düþükken, açlýk TSH düzeyi daha yüksekti. Diðer parametrelerde anlamlý farklýlýk saptanmadý. Bu sonuçlara göre hastalarýn SH’li olup olmamasýnýn hastalarýn açlýk veya postprandiyal kolestrol düzeylerini etkilemediði görülmüþtür. Üçüncü ay sonunda subklinik hipotiroidili tedavi alan (grup 1) ve tedavi almayan (Grup 2) gruplar arasýnda bazal ve postprandial deðerler kýyaslandý. Tedavi almayan grupta açlýk ve postprandial total kolesterol ve TSH deðerleri istatiksel açýdan anlamlý olarak daha yüksekken, sT4 ve sT3 deðerleri anlamlý olarak düþüktü. Ancak kolestrol seviyelerinde deðiþim miktarý (delta 0-3 ay) bakýldý ve istatistiksel fark izlenmedi.
TARTIÞMA ve SONUÇ: Çalýþmamýzda SH’li hastalarda ötiroid kontrol grubu ile karþýlaþtýrýldýðýnda; hem açlýk, hem de postprandial dönemde aterojenik kolesterol profili açýsýndan farklýlýk saptanmamýþtýr. Tiroksin tedavisi ile açlýk veya postprandial kolesterol düzeylerinde iyileþme tespit edilmemiþtir.

Anahtar Kelimeler: subklinik hipotiroidi, serum kolestrol, HDL, LDL, trigliserid

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