Kocaeli Med J. 2023; 12(3): 314-318 | DOI: 10.5505/ktd.2023.12058

The Effect of Progesterone Use During Pregnancy on 1st and 2nd Trimester Fetal Nuchal Translucency

Akin Usta¹, Ceyda Sancaklý Usta¹, Cagla Bahar Bulbul², Kübra Ak¹, Nevruz Alis Soyleyici^3
1Department Of Obstetrics And Gynecology, Balikesir University, Balikesir, Turkey
²Department Of Obstetrics And Gynecology, Balikesir Ataturk State Hospital, Balikesir, Turkey
³Department of Veterinary Histology and Embryology, Bursa Uludag University Institute of Health Sciences,Bursa, Turkey

INTRODUCTION: In the literature, there are studies related to the fact that the use of progesterone in the first trimester increases the Nuchal Translucency (NT) measurement. We aimed to investigate the effect of progesterone use on NT measurement in the first trimester and Nuchal Fold (NF) measurement in the second trimester due to threatened abortion.
METHODS: In this retrospective study, it was determined that 35 of them used vaginal progesterone due to the threatened abortion. NT and NF thicknesses of 130 pregnant women were compared with those who used progesterone (n = 35) and those who did not (n = 95). In addition, demographic data such as age, body mass index (BMI), NT, NT MoM, free beta human chorionic gonadotropin (free B-hCG), pregnancy associated plasma protein-A (PAPP-A) values in the first trimester aneuploidy screening and alpha fetoprotein (AFP) values in the second trimester aneuploidy screening, B-hCG, Estradiol (E2) values were also recorded.
RESULTS: There was no statistically significant difference between the NT values in the first trimester of the pregnant women who used progesterone due to threatened abortion and those who did not use progesterone (p = 0.1142). Considering the NF measurements, it was found that the NF thickness was significantly less in pregnant women using progesterone in the first trimester (p = 0.0268).
DISCUSSION AND CONCLUSION: Although the use of progesterone in the first trimester due to threatened abortion does not affect NT values, it may be associated with lower NF values measured in the second trimester.

Keywords: progesterone, nuchal translucency, nuchal fold, abortus imminens.

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Gebelikte Progesteron Kullanýmýnýn 1. ve 2. Trimester Fetal Ense Kalýnlýðý Üzerine Etkisi

Akin Usta¹, Ceyda Sancaklý Usta¹, Cagla Bahar Bulbul², Kübra Ak¹, Nevruz Alis Soyleyici^3
1Balýkesir Üniversitesi Týp Fakültesi, Kadýn Hastalýklarý Ve Doðum AD, Balýkesir, Türkiye
²Balýkesir Atatürk Þehir Hastanesi, Kadýn Hastalýklarý Ve Doðum Kliniði, Balýkesir, Türkiye
³Bursa Uludað Üniversitesi Saðlýk Bilimleri Enstitüsü Veterinerlik Histoloji ve Embriyoloji AD, Bursa, Türkiye

GÝRÝÞ ve AMAÇ: Literatürde ilk trimesterde progesteron kullanýmýnýn ense kalýnlýðý (NT) ölçümünü arttýrdýðý ile iliþkili çalýþmalar mevcuttur. Bu nedenle gebelikte ilk trimesterde abortus imminens nedeniyle progesteron kullanýmýnýn ilk trimesterde ölçülen NT ve ikinci trimesterde ölçülen NF deðerleri üzerine etkisini kendi gebe popülasyonumuzda deðerlendirmeyi amaçladýk.
YÖNTEM ve GEREÇLER: Bu retrospektif çalýþmada kliniðimize rutin gebelik takibi için baþvurmuþ 130 gebe kadýn deðerlendirildi. Gebeler, 35’i düþük tehdidi nedeniyle vajinal progesteron kullandýðý geriye dönük elektronik ortamda dosya verilerinden tespit edildi. 130 gebenin rutin gebelik takibi sýrasýnda yapýlan NT ve NF kalýnlýklarý progesteron kullanan (n = 35) ve kullanmayan (n = 95) gebelerde karþýlaþtýrýldý. Ayrýca hastalarýn yaþ, vücut kitle indeksi (VKÝ) gibi demografik verileri ile ikili testteki NT MoM, free beta human koryonik gonadotropin (free B-hCG), pregnancy associated plasma protein-A (PAPP-A) deðerleri ve üçlü testteki alfa fetoprotein (AFP), B-hCG, Estradiol (E2) deðerleri de kaydedildi.
BULGULAR: Abortus imminens nedeniyle progesteron kullanan gebelerle kullanmayanlarýn 1. trimesterde ölçülen NT deðerleri arasýnda istatiksel olarak anlamlý fark saptanmadý (p = 0.1142). 2. Trimesterde yapýlan NF ölçümlerine bakýldýðýnda progesteron kullanan gebelerde NF kalýnlýðýnýn anlamlý ölçüde daha az olduðu saptanmýþtýr (p = 0.0268).
TARTIÞMA ve SONUÇ: Ýlk trimesterde abortus imminens nedeniyle progesteron kullanýmý, NT deðerlerini etkilememekle birlikte ikinci trimesterde ölçülen NF deðerlerinin düþük olmasý ile iliþkili olabilir.

Anahtar Kelimeler: progesteron, ense kalýnlýðý, ense kývrýmý, abortus imminens.

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