Kocaeli Med J. 2015; 4(3): 1-3

The Findings of Echocardýography in Down syndrome Patients Who Applied to The Polyclinic of Pedýatrýc Cardiology

Onur Çaðlar Acar¹, Abdurrahman Üner², Ýbrahim Ece², Serdar Epçaçan^2
1Derince Education And Research Hospital, Department Of Pediatric Cardiology, Kocaeli, Turkey
²Yüzüncüyýl University School Of Medicine, Department Of Pediatrics, Department Of Pediatric Cardiology, Van, Turkey

INTRODUCTION: Down syndrome is the most common autosomal aneuploidy syndrome in human beings caused by the trisomy in chromosome 21. The congenital cardiac and major vascular abnormalities, caused especially by the unusual growth of endocardial cushions, is seen more commonly compared to the healthy societies in Down syndrome. In this study, the target is to define the rate of congenital cardiac disease in patients who were diagnosed with Down syndrome who applied to the Pediatric Cardiology Polyclinic of Medical Faculty of Yüzüncü Yýl University.
METHODS: This prospective research is performed in 198 cases whose Down syndrome diagnoses were made with the karyotype analyse and who were transferred to the Pediatric Cardiology Polyclinic for further examination in the dates between August 2010 - September 2012. All the patients are evaluated by echocardiography.
RESULTS: The rate of patient's age is between 1 month to 13 years. The rate of congenital cardiac disease in the patients with Down syndrome diagnoses is identified to be 54%. The atrioventricular septal defect is the most common congenital cardiac disease with the incidence rate of 49.9%. The atrioventricular septal defect is followed by; atrial septal defect (14.1%), ventricular septal defect (11.3%) and patent ductus arteriosus (8.5%).
DISCUSSION AND CONCLUSION: The rate of congenital cardiac disease in patients with Down syndrome in and around Van and the rate of atrioventricular septal defect is found consistent with the literature.

Keywords: Down syndrome, congenital cardiac disease, atrioventricular septal defect

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Çocuk Kardiyoloji Polikliniðine Baþvuran Down Sendromlu Hastalarda Ekokardiyografi Bulgularý

Onur Çaðlar Acar¹, Abdurrahman Üner², Ýbrahim Ece², Serdar Epçaçan^2
1Derince Eðitim Ve Araþtýrma Hastanesi, Çocuk Kardiyoloji Birimi, Kocaeli, Türkiye
²Yüzüncü Yýl Üniversitesi, Týp Fakültesi, Çocuk Kardiyoloji Bilim Dalý, Van, Türkiye

GÝRÝÞ ve AMAÇ: Down sendromu kromozom 21’de trizomi nedeniyle meydan gelen insanlardaki en yaygýn otozomal anöploidi sendromudur. Görülme sýklýðý toplumlara göre 319 canlý doðumda bir ile 1000 canlý doðumda bir arasýnda deðiþmektedir. Down sendromu’nda kalpte özellikle endokardiyal yastýkçýklarýn anormal geliþimi nedeniyle kalp ve büyük damarlarýn konjenital anomalileri saðlýklý topluma göre daha sýk görülmektedir. Bu çalýþmada Yüzüncü Yýl Üniversitesi Týp Fakültesi Çocuk Kardiyoloji polikliniðine müracaat eden Down sendromu tanýsý almýþ hastalarda doðumsal kalp hastalýðý sýklýðýný saptamak amaçlanmýþtýr.
YÖNTEM ve GEREÇLER: Bu prospektif araþtýrma Aðustos 2010-Eylül 2012 tarihleri arasýnda ileri tetkik için Çocuk Kardiyoloji polikliniðine gönderilen Down sendromu tanýsý karyotip analizi ile konmuþ 198 olguda yapýlmýþtýr. Tüm hastalar ekokardiyografi ile deðerlendirilmiþtir.
BULGULAR: Hastalarýn yaþ aralýðý 1 ay ile 13 yaþ arasýndadýr. Down sendromu tanýsý alan hastalarda doðumsal kalp hastalýðý oraný %54 saptanmýþtýr. Doðumsal kalp hastalýðý olarak %49.9 görülme oranýyla en sýk atriyoventriküler septal defekt görülmüþtür. Atriyoventriküler septal defekti sýrasýyla atriyal septal defekt (%14.1), ventriküler septal defekt (%11.3) ve patent duktus arteriyosus (%8.5) izlemiþtir.
TARTIÞMA ve SONUÇ: Van ve çevresindeki Down sendromlu hastalarda doðumsal kalp hastalýðý sýklýðý ve atriyoventriküler septal defekt oraný literatürle uyumlu bulunmuþtur.

Anahtar Kelimeler: Down sendromu, doðumsal kalp hastalýðý, atriyoventriküler septal defekt

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