Kocaeli Med J. 2019; 8(3): 50-54 | DOI: 10.5505/ktd.2019.60948

Does Mean Platelet Volume to Lymphocyte Ratio Associates with Irritable Bowel Syndrome and its subtypes?

Tuba Taslamacýoðlu Duman, Burçin Meryem Atak Tel
Abant Izzet Baysal Univercity Medical Faculty

INTRODUCTION: Hemogram parameters are considered as inflammatory markers in various diseases. The objective of this study was to assess mean platelet volume to lymphocyte ratio (MPVLR) of subjects with IBS and to compare to those in healthy population.

METHODS: Patients with IBS whose admissions to our outpatient internal medicine clinic were enrolled to the study. Patients with IBS were divided into two groups according to the predominant symptom, either IBS diarrhea predominant (IBS-D) or IBS constipation predominant (IBS-C). Healthy volunteers were enrolled as control group. General characteristics and MPVLR levels of the groups compared.

RESULTS: The MPVLR of IBS-C, IBS-D and control groups were 0.005 (0.001), 0.004 (0.001) and 0.003 (0.001), respectively (p<0.001). Post Hoc test revealed that MPVLR of IBS-C and IBS-D groups were similar (p=0.44) and MPVLR of control groups was significantly lower than that of the IBS-C (p<0.001) and IBS-D (p<0.001) groups.


DISCUSSION AND CONCLUSION: The main outcome of present study was that MPVLR could be used as a marker of IBS. However, it is not useful in differentiating IBS constipation predominance from IBS diarrhea predominance. In conclusion, despite increased MPVLR could not differentiate IBS constipation predominance from the IBS diarrhea predominance, it could be useful in establishing the diagnosis of IBS.

Keywords: Irritable bowel syndrome, Mean platelet volume to lymphocyte ratio, Inflamamtion

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Ortalama Trombosit Hacmi/Lenfosit Sayýsý Oraný Ýrritabl Barsak Sendromu ve Subtipleri ile Ýliþkili midir?

Tuba Taslamacýoðlu Duman, Burçin Meryem Atak Tel
Abant Ýzzet Baysal Üniversitesi Týp Fakültesi

GÝRÝÞ ve AMAÇ: Hemogram parametreleri birçok çalýþmada inflamatuvar belirteç olarak kullanýlmaktadýr.
Bu çalýþmamýzdaki amacýmýz ÝBS ve saðlýklý kontrollerdeki ortalama trombosit hacmi/lenfosit oranýnýn (MPVLR) karþýlaþtýrýlmasýdýr.

YÖNTEM ve GEREÇLER: Ýç hastalýklarý polikliniðimize baþvuran ÝBS’li hastalar çalýþmamýza alýndý. ÝBS’li hastalar diyare predominat ÝBS (IBS-D) ve konstipasyon predominant ÝBS (IBS-C) olarak iki ana gruba ayrýldý. Saðlýklý kiþilerden de kontrol grubu oluþturuldu. Çalýþmamýzda gruplarýn genel özellikleri ve MPVLR seviyeleri karþýlaþtýrýldý.

BULGULAR: IBS-C, IBS-D ve kontrol gruplardaki MPVLR sýrasýyla; 0.005 (0.001), 0.004 (0.001) ve 0.003 (0.001), (p<0.001) idi. Post Hoc testi ile IBS-C ve IBS-D gruplarýndaki MPVLR oranlarý benzer olup (p=0.44), MPVLR control grupta ise IBS-C (p<0.001) ve IBS-D (p<0.001) gruplarýndan anlamlý olarak düþük saptandý.


TARTIÞMA ve SONUÇ: MPVLR, ÝBS hastalarýnda inflamatuvar marker olarak kullanýlabileceði bu çalýþmamýzdaki ana sonucumuzdur. Ancak ÝBS gruplarý arasýnda anlamlý fark saptanmamýþtýr. Sonuçta ÝBS-C ve ÝBS-D arasýnda MPVLR benzer olmakla birlikte ÝBS hastalarýnýn saðlýklýlardan ayrýmýnda kullanýlabilir.

Anahtar Kelimeler: Ýrritabl barsak sendromu, Ortalama trombosit hacmi/lenfosit oraný, Ýnflamasyon

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