Kocaeli Med J. 2022; 11(3): 232-237 | DOI: 10.5505/ktd.2022.01336

The Pattern of Urinary Tract Infection, Antimicrobial Resistance and Associated Factors in Gölcük of Kocaeli Region

Eda Altun¹, Memnune Sena Ulu¹, Erkan Þengül^2
1University of Bahcesehir, Faculty of Medicine, Department of Nephrology, Istanbul, Turkey
²University of Health Sciences, Derince Training and Research Hospital, Department of Nephrology, Kocaeli, Turkey.

INTRODUCTION: This study aimed to evaluate antibiotic susceptibility patterns of bacterial microorganisms isolated from patients with community-acquired urinary tract infections (UTIs) in our region.
METHODS: Between November 2019 and November 2020, 294 patients whose urine culture was positive in the Nephrology outpatient clinic of Gölcük Necati Çelik State Hospital were included in the study. Patient information was recorded from medical files retrospectively
RESULTS: Escherichia coli (E. coli) was the most common isolated pathogen in culture (76.2%) with Klebsiella spp. ranking second, (10.5%), followed by Pseudomonas and Enterococcus. The incidence of diabetes mellitus (DM) among the 294 patients was 41.5%; the incidence of hypertension was 53%; 3.1% had urinary catheters, and 9.5% (28) of the woman patients were pregnant.
DISCUSSION AND CONCLUSION: This study determined that E.coli was the predominant bacterial pathogen of community-acquired UTIs in our region. We have found that resistance against ceftriaxone, ceftazidime, cefixime, amoxycillin-clavulanic acid, and trimethoprim-sulfamethoxazole was most frequently observed both in the general population as well as in patients with diabetes mellitus. However, resistance against nitrofurantoin and fosfomycin was found to be very low. We believe that the evaluation of antibiotic resistance by the district against microorganisms should be done periodically, and the information obtained from these evaluations should be used when initiating the proper empirical treatment.

Keywords: urinary tract infection, bacterýuria, antibiotic resistance

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Kocaeli Ýli Gölcük Bölgesinde Ýdrar Yolu Enfeksiyonu, Antibiyotik Direnci ve Ýliþkili Faktörler

Eda Altun¹, Memnune Sena Ulu¹, Erkan Þengül^2
1Bahçeþehir Üniversitesi Týp Fakültesi, Nefroloji Kliniði, Ýstanbul, Türkiye
²Saðlýk Bilimleri Üniversitesi, Kocaeli Derince Eðitim Araþtýrma Hastanesi, Nefroloji Kliniði, Kocaeli, Türkiye

GÝRÝÞ ve AMAÇ: Bu çalýþmanýn amacý bölgemizde toplum kökenli idrar yolu enfeksiyonu (ÝYE) olan hastalardan izole edilen bakteriyel mikroorganizmalarýn sýklýðýný ve antibiyotik duyarlýlýk paternlerini deðerlendirmektir.
YÖNTEM ve GEREÇLER: Kasým 2019-Kasým 2020 tarihleri arasýnda Gölcük Necati Çelik Devlet Hastanesi Nefroloji polikliniðinde idrar kültüründe üreme saptanan 294 hasta çalýþmaya dahil edildi. Hasta bilgileri geriye dönük olarak hastane otomasyon sisteminden kaydedildi.
BULGULAR: En sýk izole edilen patojenin E.coli (%76,2) olduðu ikinci sýrada Klebsiella spp. (%10,5) olduðu ve bunu Pseudomonas ve Enterococcus suþlarýnýn izlediði saptandý. Diabetes mellitus insidansý %41,5, hipertansiyon insidansý %53 idi. Hastalarýn %3,1'inde üriner kateter mevcuttu ve kadýn hastalarýn %9,5'i (28) gebe idi.
TARTIÞMA ve SONUÇ: Bölgemizde toplum kökenli ÝYE'lerde baskýn bakteriyel patojeninin E.coli olduðu belirlendi. Seftriakson, seftazidim, sefiksim, amoksisilin-klavulanik asit, trimetoprim-sülfametoksazole karþý direncin hem genel popülasyonda hem de diabetes mellitus'lu hastalarda en sýk gözlendiði, nitrofurantoin ve fosfomisine karþý ise direnç oranýnýn oldukça düþük olduðu gözlendi. Bölgelere göre antibiyotik direnç oranlarýnýn periyodik deðerlendirilmesi ve bu deðerlendirmelerden elde edilen bilgilerin doðru ampirik tedavi seçiminde kullanýlmasý gerektiðine inanýyoruz.

Anahtar Kelimeler: idrar yolu enfeksiyonu, bakteriüri, antibiyotik direnci

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