Kocaeli Med J. 2021; 10(1): 61-71 | DOI: 10.5505/ktd.2021.76301

Perinatal Characteristics and Clinical Follow-up of Infants Born from Mothers Diagnosed with COVID-19 in Pandemic Hospitals of Kocaeli Province: 4-Months Retrospective Study Results

Ýlkay Er¹, Harun Kaçar², Hüseyin Aktürk^3
1University of Health Sciences, Kocaeli Derince Training and Research Hospital, Neonatology, Kocaeli, Turkey
²Kocaeli Darýca Farabi Training and Research Hospital, Child Health and Diseases,Kocaeli, Turkey
³University of Health Sciences, Kocaeli Derince Training and Research Hospital, Pediatric Infectious Diseases,Kocaeli, Turkey

INTRODUCTION: Coronavirus-19 infection (COVID-19), has been affected pregnant women and newborns more and more every day. In our study, babies born from mothers diagnosed with COVID-19 in pandemic hospitals of Kocaeli province and their characteristics were analyzed retrospectively. It is aimed to determine prognosis of these babies in our city and to contribute to their clinical management.
METHODS: In the study, hospital data of mothers diagnosed with COVID-19 and their babies were collected and analyzed between July 1,2020 and October 31,2020. Newborns with positive respiratory tract test were identified as definite COVID-19 case.
RESULTS: During four-months, a total of 72 newborns were hospitalized. Of those, 10 with postnatal COVID-19 diagnosed and 20 whose mothers had negative COVID-19 test were excluded from study. Pregnant women mostly presented with fever±cough. High CRP, D-dimer and fibrinogen values were remarkable. 30.9% had comorbidity. 23.8% needed oxygen, and received COVID-19 specific treatment. Cesarean rate was 78.6%. All babies born term and had appropiate-birth weight. 2 Out of 42 babies were detected COVID-PCR positivity in nasopharyngeal-nasal swap (%4.8), and were presented with fever/respiratory distress postnatally. D-dimer, LDH elevations were detected in both, additionally CK, borderline AST elevations in one. They discharged in good-health after 7-10 days. Most of babies were fed with formula and followed-up in isolation. All received supportive treatment. The mother-infant survival rate was 100%.
DISCUSSION AND CONCLUSION: During the study, it was determined that babies born from mothers diagnosed with COVID-19 in our city had good prognosis. Multi-center studies with large numbers are needed for precise data.

Keywords: COVID-19, Kocaeli, vulnerable population, newborn, pregnant

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Kocaeli Ýli Pandemi Hastanelerinde COVID-19 Tanýlý Annelerden Doðan Bebeklerin Perinatal Özellikleri ve Klinik Ýzlemleri: 4 Aylýk Retrospektif Çalýþma Sonuçlarý

Ýlkay Er¹, Harun Kaçar², Hüseyin Aktürk^3
1SBÜ Kocaeli Derince Eðitim ve Araþtýrma Hastanesi, Yenidoðan, Kocaeli
²Kocaeli Darýca Farabi Eðitim ve Araþtýrma Hastanesi, Çocuk Saðlýðý ve Hastalýklarý, Kocaeli
³SBÜ Kocaeli Derince Eðitim ve Araþtýrma Hastanesi, Çocuk Enfeksiyon Hastalýklarý, Kocaeli

GÝRÝÞ ve AMAÇ: Tüm dünyada pandemiye neden olan Coronavirüs-19 enfeksiyonu (COVID-19), gebeleri ve yenidoðan bebekleri her geçen gün daha fazla etkilemektedir. Çalýþmamýzda Kocaeli ili pandemi hastanelerinde COVID-19 tanýlý annelerden doðan bebekler ve özellikleri retrospektif olarak incelenmiþtir. Elde edilen bulgularla bu bebeklerin ilimizdeki prognozunun belirlenmesi ve klinik yönetimine katkýda bulunulmasý amaçlanmýþtýr.
YÖNTEM ve GEREÇLER: Çalýþmada 1.Temmuz.2020-31.Ekim.2020 tarihleri arasýnda COVID-19 tanýlý anneler ve bebeklerine ait hastane verileri toplandý, analiz edildi. Solunum yolu testi pozitif yenidoðanlar kesin COVID-19 vakasý olarak tanýmlandý.
BULGULAR: Dört aylýk çalýþma sürecinde toplam 72 yenidoðan izlenmiþti. Bu bebeklerin 10 tanesi postnatal COVID-19 tanýsý aldýðýndan, 20 tanesi de annelerinin COVID-19 testleri negatif sonuçlandýðýndan çalýþmaya alýnmadý. COVID-19 tanýlý gebelerin çoðunluðu ateþ±öksürükle baþvurmuþtu. Yüksek CRP, D-dimer ve fibrinojen deðerleri dikkat çekiciydi. %30.9'unun komorbiditesi mevcuttu. Ýzlemde %23.8'i oksijene ihtiyaç duydu ve COVID-19 spesifik tedavi aldý. Sezaryan oraný %78.6’ydý. Çalýþmadaki tüm bebekler zamanýnda doðdular, gebelik haftasýna göre normal aðýrlýktaydýlar. 42 bebekten 2 bebeðin (%4.8) nazofaringeal-nazal sürüntüsünde COVID-PCR pozitifliði saptandý. Doðum sonrasý birinde ateþ, diðerinde solunum sýkýntýsý oldu. Her iki bebekte D-dimer ve LDH yüksekliði, birinde ek olarak CK ve sýnýrda AST yüksekliði saptandý. 7-10 gün sonra saðlýkla taburcu edildiler. Bebeklerin çoðunluðu formülayla beslendi ve izole olarak izlendi. Tümü destekleyici tedavi aldý. Anne-bebek saðkalým oraný %100’dü.
TARTIÞMA ve SONUÇ: Çalýþma sürecinde ilimizdeki COVID-19 tanýlý annelerden doðan bebeklerin prognozunun iyi olduðu belirlenmiþtir. Kesin veriler için çok merkezli, geniþ sayýda çalýþmalara ihtiyaç vardýr.

Anahtar Kelimeler: COVID-19, Kocaeli, savunmasýz popülasyon, yenidoðan, gebe

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