Kocaeli Med J. 2017; 6(3): 30-35

Clinical significance of repolarization parameters in Brugada Syndrome patients

Kývanç Yalýn¹, Tümer Erdem Güler², Tolga Aksu², Ebru Gölcük³, Kamil Adalet^4
1Usak University, Faculty Of Medicine, Department Of Cardiology, Uþak
²Kocaeli Derince Education And Research Hospital, Cardiology Clinic, Kocaeli
³Balikesir University, Faculty Of Medicine, Department Of Cardiology, Balikesir
⁴Istanbul University, Istanbul Faculty Of Medicine, Department Of Cardiology, Istanbul

INTRODUCTION: Brugada syndrome (BS) is a genetic disease with increased risk of sudden cardiac death. Increased T wave alternans (TWA) and prolonged T wave peak to end (Tp-e) interval are linked to sudden cardiac death. In the present study, we investigated the role of TWA and Tp-e interval in BS.

METHODS: Thirteen BS and 11 controls were included. TWA and ECG were recorded. Patients and controls were followed for ventricular arrhythmias.
RESULTS: TWA study was negative in BS and controls. Tp-e interval was longer in BS than controls. Furthermore, during f/u all patients with ventricular arrhythmiashad Tp-e interval longer than 100 ms.

DISCUSSION AND CONCLUSION: TWA is an inappropriate test for BS, prolonger Tpe may be related to increased risk in BS patients.

Keywords: Brugada Syndrome, T wave alternates, Tp-e interval, repolarization, ventricular arrhythmia

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Brugada Sendromu hastalarýnda repolarizasyon parametrelerinin klinik önemi

Kývanç Yalýn¹, Tümer Erdem Güler², Tolga Aksu², Ebru Gölcük³, Kamil Adalet^4
1Uþak Üniversitesi, Týp Fakültesi, Kardiyoloji Anabilim Dalý, Uþak
²Kocaeli Derince Eðitim Ve Araþtýrma Hastanesi, Kardiyoloji Kliniði, Kocaeli
³Balýkesir Üniversitesi, Týp Fakültesi, Kardiyoloji Anabilim Dalý, Balýkesir
⁴Ýstanbul Üniversitesi, Ýstanbul Týp Fakültesi, Kardiyoloji Anabilim Dalý, Ýstanbul

GÝRÝÞ ve AMAÇ: Brugada Sendromu (BS) ani ölüm riskinin arttýðý kalýtsal bir hastalýktýr. Mevcut risk parametreleri yetersizdir. Artmýþ T dalga alternansý (TDA) ve uzamýþ T dalgasý pik-son süresi (Tp-e) ani kardiyak ölüm ile iliþkilidir. Bu çalýþmada TDA ve Tp-e süresinin BS hastalarýndaki rolü araþtýrýlmýþtýr.
YÖNTEM ve GEREÇLER: Çalýþmaya 13 BS hastasý ve 11 kontrol alýnmýþtýr. BS ve kontrollerde TDA ve EKG kaydedilmiþtir. Hastalar ve kontroler ventriküler aritmi açýsýndan takip edilmiþtir.

BULGULAR: BS ve kontrollerde TDA negatif saptanmýþtýr. Ancak BS hastalarýnda Tp-e süresi kontrollere göre daha uzun saptanmýþtýr. Ayrýca takipte ventriküler aritmi geliþen hastalarýn tümünde Tp-e 100 ms’ nin üzerindedir.

TARTIÞMA ve SONUÇ: BS hastalarýnda TDA uygun olmayan bir testtir, Tp-e süresinin uzamasý BS hastalarýnda artmýþ risk ile iliþkili olabilir.

Anahtar Kelimeler: Brugada Sendromu, T dalga alternansý, Tp-e intervali, repolarizasyon, ventriküler aritmi

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