Kocaeli Med J. 2017; 6(3): 77-80

Colchicine related pancytopenia and polyneuropathy

Ceren Erdoðan¹, Esra Terzi&775; Demi&775;rsoy^2
1Kocaeli̇ Deri̇nce Research And Trai̇ni̇ng Hospi̇tal, Department Of Ýnternal Medi̇ci̇ne, Kocaeli̇
²Kocaeli̇ Deri̇nce Research And Trai̇ni̇ng Hospi̇tal, Department Of Hematology, Kocaeli̇

Colchine is used in the treatment of different diseases such as attacks of gout arthritis, familial Mediterannean fever, Behçet disease. As colchicine is a anti-mitotic agent, the most side effects of oral colchicine ara gastrointestinal symtoms including diarrhea, nausea, vomitting and abdominal pain. The most serious effects include myelosuppresyon, myoneuropathy and multiple organ failure which are rare. This occurs with overdose or therapeutic dosing in patients with reduced clerance of colchicine due to renal insufficiency and hepatic dysfunction.

Keywords: colchicine, side effects, pancytopenia, polyneuropathy

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Kolsiþin iliþkili pansitopeni ve polinöropati

Ceren Erdoðan¹, Esra Terzi&775; Demi&775;rsoy^2
1Kocaeli̇ Deri̇nce Eði̇ti̇m Ve Araþtýrma Hastanesi̇, Ýç Hastalýklarý Kli̇ni̇ði̇, Kocaeli̇
²Kocaeli̇ Deri̇nce Eði̇ti̇m Ve Araþtýrma Hastanesi̇, Hematoloji̇ Kli̇ni̇ði̇, Kocaeli̇

Kolsiþin gut artriti ataklarý, ailevi Akdeniz ateþi, Behçet hastalýðý gibi farklý hastalýklarýn tedavisinde kullanýlýr. Anti-mitotik bir ajan olan kolsiþinin en sýk yan etkisi ishal, bulantý, kusma, karýn aðrýsý gibi gastrointestinal semptomlardýr. Miyelosupresyon, miyonöropati ve multiple organ yetersizliðini içeren ciddi yan etkiler nadirdir. Bu yan etkiler overdozda veya tedavi dozunda kullanýmý olan böbrek yetmezliði ve karaciðer fonksiyon bozukluðundan dolayý kolsiþin atýlýmý azalan hastalarda meydana gelir

Anahtar Kelimeler: Kolsiþin, Yan etkiler, Pansitopeni, Polinöropati

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