Kocaeli Med J. 2023; 12(2): 221-225 | DOI: 10.5505/ktd.2023.25665

Effect of Different Sugammadex Doses on Plasma Free Hormone Levels

Ahmet Yuksek¹, Cevdet Yardýmcý², Gamze Talih³, Ayþe Yeþim Göçmen^2
1UHS Kocaeli Derince Education and Research Hospital, Department of Anesthesiology and Reanimation, Kocaeli, Turkey
²Yozgat Bozok University Faculty of Medicine, Department of Anesthesiology and Reanimation, Yozgat, Turkey
³Erciyes University Faculty of Medicine, Department of Anesthesiology and Reanimation, Kayseri, Turkey

INTRODUCTION: Sugammadex is a new generation cyclodextine ring with high affinity for steroidal normuscular blockers. Its effect on plasma steroid hormone levels has been the subject of some studies. In this study, the effects of high-dose sugammadex administration on both steroid hormones and growth hormone were investigated.
METHODS: For our experimental animal study, winstar albino rats administered 0mg/kg, 4mg/kg and 16mg/kg sugammadex under anesthesia were divided into 3 groups. Plasma estrogen, progesterone, total and free testosterone, cortisol and growth hormone levels were measured at the 15th minute after sugammadex administration in rats and compared between groups.
RESULTS: In the high-dose sugammadex group, plasma progesterone (p<0.05) and cortisol levels (p<0.05), were lower, growth hormone (p<0.05) and free testosterone levels (p<0.05 were higher, and estrogen (p>0.05) and total testosterone levels (p>0.05) were statistically similar to the other groups.
DISCUSSION AND CONCLUSION: There are different findings in the literature regarding the effects of sugammadex on steroid hormone levels. Sugammadex administered at high doses provides a more effective change in hormone levels. It also revealed the idea that the change in growth hormone levels may have an effect on the plasma proteins of sugammadex. Our finding regarding the decrease in cortisol levels with high-dose sugammadex is remarkable in terms of stress response to surgery.
Sugammadex administered at high doses affected both steroid and non-steroidal hormone levels in rats. High-dose sugammadex increased plasma free growth hormone in rats. Our findings suggest that sugammadex also affects hormone-binding proteins. The clinical significance of the findings should be supported by further studies

Keywords: sugammadex, steroid hormone, animal model, anesthesiology

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Farklý Sugammadeks Dozlarýnýn Plazma Serbest Hormon Düzeylerine Etkisi

Ahmet Yuksek¹, Cevdet Yardýmcý², Gamze Talih³, Ayþe Yeþim Göçmen^2
1SBÜ Kocaeli Derince Eðitim ve Araþtýrma Hastanesi, Anesteziyoloji ve Reanimasyon Kliniði, Kocaeli, Türkiye
²Yozgat Bozok Universitesi Týp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalý, Yozgat, Türkiye
³Erciyes Üniversitesi Týp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalý, Kayseri, Türkiye

GÝRÝÞ ve AMAÇ: Sugammadeks steroidal yapýdaki normusukler blokerlere yüksek afinitesi olan yeni nesil bir siklodekstin halkasýdýr. Plazma steroid hormon seviyelerine etkisi bazý çalýþmalarýn konusu olmuþtur. Bu çalýþmada ise yüksek doz sugammadeks uygulamasýnýn hem steroid hormonlar hemde büyüme hormonu üzerine etkileri araþtýrýlmýþtýr.
YÖNTEM ve GEREÇLER: Deneysel hayvan çalýþmamýz için anestezi altýnda 0mg/kg, 4mg/kg ve 16mg/kg sugammadeks uygulanan winstar albino cinsi ratlar 3 gruba ayrýlmýþtýr. Ratlardan sugammadeks uygulamasý sonrasý 15. dakikada plazma östrojen, progesteron, total ve serbest testesteron, kortizol ve büyüme hormonu seviyeleri bakýlmýþ ve gruplar arasýnda karþýlaþtýrýlmýþtýr.
BULGULAR: Yüksek doz sugammadeks uygulanan grupta plazma progesteron (p<0.05) ve kortizol seviyesi daha az (p<0.05), büyüme hormonu (p<0.05) ve serbest testesteron seviyesi daha fazla(p<0.05), östrojen (p>0.05) ve total testesteron seviyesi (p>0.05) ise diðer gruplar ile istatistiksel olarak benzer bulunmuþtur
TARTIÞMA ve SONUÇ: Literatürde sugammadeksin steroid hormon seviyelerine etkileri ile ilgili farklý bulgular mevcuttur. Bulgularýmýz yüksek dozda uygulanan sugammadeksin ratlarda hormon seviyelerinde daha etkin bir deðiþim saðladýðýný düþündürmektedir. Ayrýca büyüme hormonu seviyelerindeki deðiþimin sugammadeksin plazma proteinler ile etkileþimi de olabileceði fikrini ortaya çýkarmýþtýr. Yüksek doz sugammadeks ile kortizol seviyelerindeki azalma ise cerrahiye stres yanýt açýsýndan dikkate deðerdir.
Sonuç: Yüksek dozlarda uygulanan sugammadeks ratlarda hem steroid hemde non steroidal hormon seviyelerini etkilemiþtir. Yüksek doz sugammadeks ratlarda plazma serbest büyüme hormonunda artýþ saðlamýþtýr. Bulgularýmýz sugammadeksin hormon baðlayýcý proteinleri de etkilediðini düþündürmektedir. Sugammadeksin bulgularýn klinik önemi daha fazla çalýþma ile desteklenmelidir.

Anahtar Kelimeler: sugammadeks, steroid hormon, hayvan modeli, anesteziyoloji

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