Kocaeli Med J. 2019; 8(2): 126-133 | DOI: 10.5505/ktd.2019.50251

Simple and New Echocardiographic Parameter Related to Aging: Descending Aortic Continuous Wave Doppler Systolic Peak Gradient

ONUR ARGAN¹, SERDAR BOZYEL^2
1Balikesir University Medical Faculty, Cardiology Department, Balikesir, Turkey
²Derince Training and Research Hospital, Department of Cardiology, Kocaeli, Turkey

INTRODUCTION: The world inhabitants increasing to grow older fastly, due to rising longevity.A new parameters related to cardiovascular aging may help to understand cardiac pathophysiology and prevention of cardiac disorders.The aim of the study was to find out a possible relationship between descending aortic continuous wave doppler systolic peak gradient and aging,age related illnesses.
METHODS: The study group was composed of 372 people.Aortic coarctation patients and under 18 years old participants exluded to the study.Continuous wave doppler measurements from suprasternal window at supine position were recorded with the cursor parallel to main flow of direction in descending aorta.Descending aortic continuous wave doppler systolic peak gradient was obtained from all participants and correlations were evaluated between participants caracteristics,echocardiographic,biochemical parameters and age.
RESULTS: When descending aortic continuous wave doppler systolic peak gradient was analyzed,there was negative correlations with age (r= -0.499,p<0.001);creatinine (r=-0.217,p<0.001);urea (r=-0.289,p<0.001);Hba1c (r=-0.252,p<0.001);LVEDD (r=-0.188,p<0.001);LVESD (r=-0.200,p<0.001);IVS (r=-0.259,p<0.001);PW (r=-0.248,p<0.001);LA (r=-0.272,p<0.001);PAP (r=-0.217,p<0.001); E/E’(r=-0.185,p<0.001); ascending aortic diameter (r=-0.269,p<0.001) and positive correlations with eGFR (r=0.395,p<0.001),EF (r= 0.266,p<0.001).
In Mann Whitney U test, descending aortic continuous wave doppler systolic peak gradient was significantly lower in hypertension (p<0.001); coronary artery disease (p<0.001); atrial fibrillation (p<0.001); systolic heart failure patients (p<0.001) when compared to those without this disease.In stepwise linear regression analysis, significant independent correlates of descending aortic continuous wave doppler systolic peak gradient was only age (p<0.001).

DISCUSSION AND CONCLUSION: Measurement of descending aortic continuous wave doppler systolic peak gradient is noninvasive,practical,repeatable and simple method and independently related to the aging.This parameter can be easily feasible in clinical practice as an indicator of aging.

Keywords: Aging, elderly, descending aorta, continuous wave doppler

---

Yaþlanma ile Ýliþkili Basit ve Yeni bir Parametre: Desendan Aorta Sürekli Dalga Doppler Sistolik Pik Gradient

ONUR ARGAN¹, SERDAR BOZYEL^2
1Balýkesir Üniversitesi Týp Fakültesi, Kardiyoloji Ana Bilim Dalý, Balýkesir, Turkey
²Derince Eðitim Araþtýrma Hastanesi, Kardiyoloji Ana Bilim Dalý, Kocaeli, Turkey

GÝRÝÞ ve AMAÇ: Artan insan ömrü nedeniyle dünyadaki yaþlý popülasyon hýzla artmaktadýr. Yaþlanma ile ilgili yeni parametreler yaþlanmanýn fizyopatolojisini ve kardiyovasküler hastalýklardan korunmada fayda saðlayabilir. Bu çalýþmanýn amacý yaþlanma ve yaþlanma ile iliþkili hastalýklar ile desendan aorta CW doppler sistolik pik gradient arasýndaki iliþkiyi saptamaktýr.
YÖNTEM ve GEREÇLER: Çalýþmaya 372 katýlýmcý dahil edildi. Aort koarktasyonu olan hastalar ve 18 yaþ altý katýlýmcýlar çalýþma dýþý býrakýldý. Yatar pozisyonda, suprasternal pencereden desendan aortaya paralel olarak sürekli dalga doppler ölçümleri kaydedildi. Aortik sürekli dalga doppler sistolik pik gradienti tüm katýlýmcýlardan elde edildi. Katýlýmcýlarýn karakteristikleri, ekokardiyografik, biyokimyasal parametreleri ile yaþ arasýndaki iliþki deðerlendirildi.
BULGULAR: Desendan aortik sürekli dalga doppler sistolik pik gradyaný incelendiðinde yaþ ile negatif (r =-0.499,p<0.001);kreatinin (r=-0.217,p <0.001); üre (r =-0.289,p<0.001); Hba1c (r = -0.252 p <0.001); LVEDD (r =-0.188, p<0.001); LVESD (r =-0.200,p <0.001); IVS (r=-0.259,p<0.001); PW (r =-0.248, p<0.001); LA (r=-0.272, p<0.001); PAP (r=-0.217, p<0.001); E / E '(r =-0.185, p<0.001), eGFR (Cockcroft-Gault mL / dk) (r =0.395,p <0.001) ve EF (r =0.266 p<0.001) ile pozitif korelasyon saptandý.
MannWhitney U analizinde desendan aorta sürekli dalga doppler sistolik pik gradyaný hipertansiyon (p<0.001), koroner arter hastalýðý (p <0.001), atrial fibrilasyon (p<0.001), ve sistolik kalp yetmezliði hastalarýnda (p<0.001) anlamlý olarak daha düþük saptandý.
Stepwise lineer regresyon analizinde, desendan aorta sürekli dalga doppler sistolik pik gradientin ile yaþ arasýnda baðýmsýz korelasyon saptandý (p<0.001).

TARTIÞMA ve SONUÇ: Desendan aorta sürekli dalga doppler sistolik pik gradientinin ölçümü yaþlanma ile iliþkili noninvaziv, pratik, tekrarlanabilir ve basit bir yöntemdir. Bu parametre klinik pratikte yaþlanmanýn bir göstergesi olarak kolayca kullanýlabilir.

Anahtar Kelimeler: Yaþlanma, yaþlýlýk, Desendan aorta, sürekli dalga doppler

---

CITE